diff --git a/src/net_processing.cpp b/src/net_processing.cpp
index 7387f78b931..f5f81a65f56 100644
--- a/src/net_processing.cpp
+++ b/src/net_processing.cpp
@@ -4345,6 +4345,14 @@ void PeerManagerImpl::ProcessMessage(Peer& peer, CNode& pfrom, const std::string
     if (msg_type == NetMsgType::GETBLOCKTXN) {
         BlockTransactionsRequest req;
         vRecv >> req;
+
+        // No legitimate reason to send indexes empty
+        if (req.indexes.empty()) {
+            LogDebug(BCLog::NET, "getblocktxn received with no transaction indexes, %s", pfrom.DisconnectMsg());
+            pfrom.fDisconnect = true;
+            return;
+        }
+
         // Verify differential encoding invariant: indexes must be strictly increasing
         // DifferenceFormatter should guarantee this property during deserialization
         for (size_t i = 1; i < req.indexes.size(); ++i) {
diff --git a/test/functional/p2p_compactblocks.py b/test/functional/p2p_compactblocks.py
index 8db0fab75bd..7466b833ac2 100755
--- a/test/functional/p2p_compactblocks.py
+++ b/test/functional/p2p_compactblocks.py
@@ -843,6 +843,17 @@ class CompactBlocksTest(BitcoinTestFramework):
         msg = msg_cmpctblock(comp_block.to_p2p())
         test_node.send_await_disconnect(msg)
 
+    def test_empty_getblocktxn_disconnects(self):
+        self.log.info("Testing empty getblocktxn disconnects the peer...")
+        node = self.nodes[0]
+        block_hash = int(node.getbestblockhash(), 16)
+        peer = node.add_p2p_connection(P2PInterface())
+        msg = msg_getblocktxn()
+        msg.block_txn_request = BlockTransactionsRequest(blockhash=block_hash, indexes=[])
+        with node.assert_debug_log(['getblocktxn received with no transaction indexes']):
+            peer.send_without_ping(msg)
+            peer.wait_for_disconnect()
+
     # peer generates a block and sends it to node, which makes the peer a
     # candidate for high-bandwidth 'to' (up to 3 peers according to BIP 152)
     def make_peer_hb_to_candidate(self, node, peer):
@@ -1097,6 +1108,7 @@ class CompactBlocksTest(BitcoinTestFramework):
 
         self.log.info("Testing handling of invalid compact blocks...")
         self.test_invalid_tx_in_compactblock(self.segwit_node)
+        self.test_empty_getblocktxn_disconnects()
 
         # The previous test will lead to a disconnection. Reconnect before continuing.
         self.segwit_node = self.nodes[0].add_p2p_connection(TestP2PConn())