diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 4f0ed47b951..6f7532c0a55 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -67,7 +67,7 @@ jobs:
           echo "TEST_BASE=$(git rev-list -n$((${{ env.MAX_COUNT }} + 1)) --reverse HEAD $EXCLUDE_MERGE_BASE_ANCESTORS | head -1)" >> "$GITHUB_ENV"
       - run: |
           sudo apt-get update
-          sudo apt-get install clang ccache build-essential cmake pkgconf python3-zmq libevent-dev libboost-dev libsqlite3-dev libdb++-dev systemtap-sdt-dev libzmq3-dev qtbase5-dev qttools5-dev qttools5-dev-tools qtwayland5 libqrencode-dev -y
+          sudo apt-get install clang ccache build-essential cmake ninja-build pkgconf python3-zmq libevent-dev libboost-dev libsqlite3-dev libdb++-dev systemtap-sdt-dev libzmq3-dev qt6-base-dev qt6-tools-dev qt6-l10n-tools libqrencode-dev -y
       - name: Compile and run tests
         run: |
           # Run tests on commits after the last merge commit and before the PR head commit
@@ -124,7 +124,7 @@ jobs:
         run: |
           # A workaround for "The `brew link` step did not complete successfully" error.
           brew install --quiet python@3 || brew link --overwrite python@3
-          brew install --quiet coreutils ninja pkgconf gnu-getopt ccache boost libevent zeromq qt@5 qrencode
+          brew install --quiet coreutils ninja pkgconf gnu-getopt ccache boost libevent zeromq qt@6 qrencode
 
       - name: Set Ccache directory
         run: echo "CCACHE_DIR=${RUNNER_TEMP}/ccache_dir" >> "$GITHUB_ENV"
diff --git a/ci/test/00_setup_env.sh b/ci/test/00_setup_env.sh
index 9f794c25235..cf8fbb006f5 100755
--- a/ci/test/00_setup_env.sh
+++ b/ci/test/00_setup_env.sh
@@ -64,7 +64,7 @@ export BASE_OUTDIR=${BASE_OUTDIR:-$BASE_SCRATCH_DIR/out}
 # The folder for previous release binaries.
 # This folder exists only on the ci guest, and on the ci host as a volume.
 export PREVIOUS_RELEASES_DIR=${PREVIOUS_RELEASES_DIR:-$BASE_ROOT_DIR/prev_releases}
-export CI_BASE_PACKAGES=${CI_BASE_PACKAGES:-build-essential pkgconf curl ca-certificates ccache python3 rsync git procps bison e2fsprogs cmake}
+export CI_BASE_PACKAGES=${CI_BASE_PACKAGES:-build-essential pkgconf curl ca-certificates ccache python3 rsync git procps bison e2fsprogs cmake ninja-build}
 export GOAL=${GOAL:-install}
 export DIR_QA_ASSETS=${DIR_QA_ASSETS:-${BASE_SCRATCH_DIR}/qa-assets}
 export CI_RETRY_EXE=${CI_RETRY_EXE:-"retry --"}
diff --git a/ci/test/00_setup_env_native_asan.sh b/ci/test/00_setup_env_native_asan.sh
index 4066b14fc9b..bd67dba6888 100755
--- a/ci/test/00_setup_env_native_asan.sh
+++ b/ci/test/00_setup_env_native_asan.sh
@@ -20,7 +20,7 @@ fi
 
 export CONTAINER_NAME=ci_native_asan
 export APT_LLVM_V="20"
-export PACKAGES="systemtap-sdt-dev clang-${APT_LLVM_V} llvm-${APT_LLVM_V} libclang-rt-${APT_LLVM_V}-dev python3-zmq qtbase5-dev qttools5-dev qttools5-dev-tools libevent-dev libboost-dev libdb5.3++-dev libzmq3-dev libqrencode-dev libsqlite3-dev ${BPFCC_PACKAGE}"
+export PACKAGES="systemtap-sdt-dev clang-${APT_LLVM_V} llvm-${APT_LLVM_V} libclang-rt-${APT_LLVM_V}-dev python3-zmq qt6-base-dev qt6-tools-dev qt6-l10n-tools libevent-dev libboost-dev libdb5.3++-dev libzmq3-dev libqrencode-dev libsqlite3-dev ${BPFCC_PACKAGE}"
 export NO_DEPENDS=1
 export GOAL="install"
 export BITCOIN_CONFIG="\
diff --git a/ci/test/00_setup_env_native_centos.sh b/ci/test/00_setup_env_native_centos.sh
index c423d788eb8..4f06a29daf4 100755
--- a/ci/test/00_setup_env_native_centos.sh
+++ b/ci/test/00_setup_env_native_centos.sh
@@ -8,7 +8,7 @@ export LC_ALL=C.UTF-8
 
 export CONTAINER_NAME=ci_native_centos
 export CI_IMAGE_NAME_TAG="quay.io/centos/centos:stream10"
-export CI_BASE_PACKAGES="gcc-c++ glibc-devel libstdc++-devel ccache make git python3 python3-pip which patch xz procps-ng ksh rsync coreutils bison e2fsprogs cmake"
+export CI_BASE_PACKAGES="gcc-c++ glibc-devel libstdc++-devel ccache make ninja-build git python3 python3-pip which patch xz procps-ng ksh rsync coreutils bison e2fsprogs cmake"
 export PIP_PACKAGES="pyzmq"
 export DEP_OPTS="DEBUG=1"  # Temporarily enable a DEBUG=1 build to check for GCC-bug-117966 regressions. This can be removed once the minimum GCC version is bumped to 12 in the previous releases task, see https://github.com/bitcoin/bitcoin/issues/31436#issuecomment-2530717875
 export GOAL="install"
diff --git a/ci/test/00_setup_env_native_tidy.sh b/ci/test/00_setup_env_native_tidy.sh
index b5277d13949..08a7cbbf7e4 100755
--- a/ci/test/00_setup_env_native_tidy.sh
+++ b/ci/test/00_setup_env_native_tidy.sh
@@ -10,7 +10,7 @@ export CI_IMAGE_NAME_TAG="mirror.gcr.io/ubuntu:24.04"
 export CONTAINER_NAME=ci_native_tidy
 export TIDY_LLVM_V="19"
 export APT_LLVM_V="${TIDY_LLVM_V}"
-export PACKAGES="clang-${TIDY_LLVM_V} libclang-${TIDY_LLVM_V}-dev llvm-${TIDY_LLVM_V}-dev libomp-${TIDY_LLVM_V}-dev clang-tidy-${TIDY_LLVM_V} jq libevent-dev libboost-dev libzmq3-dev systemtap-sdt-dev qtbase5-dev qttools5-dev qttools5-dev-tools libqrencode-dev libsqlite3-dev libdb++-dev"
+export PACKAGES="clang-${TIDY_LLVM_V} libclang-${TIDY_LLVM_V}-dev llvm-${TIDY_LLVM_V}-dev libomp-${TIDY_LLVM_V}-dev clang-tidy-${TIDY_LLVM_V} jq libevent-dev libboost-dev libzmq3-dev systemtap-sdt-dev qt6-base-dev qt6-tools-dev qt6-l10n-tools libqrencode-dev libsqlite3-dev libdb++-dev"
 export NO_DEPENDS=1
 export RUN_UNIT_TESTS=false
 export RUN_FUNCTIONAL_TESTS=false
diff --git a/ci/test/01_base_install.sh b/ci/test/01_base_install.sh
index 1344563268f..d61aaca3f0c 100755
--- a/ci/test/01_base_install.sh
+++ b/ci/test/01_base_install.sh
@@ -34,7 +34,8 @@ fi
 
 if [[ $CI_IMAGE_NAME_TAG == *centos* ]]; then
   bash -c "dnf -y install epel-release"
-  bash -c "dnf -y --allowerasing install $CI_BASE_PACKAGES $PACKAGES"
+  # The ninja-build package is available in the CRB repository.
+  bash -c "dnf -y --allowerasing --enablerepo crb install $CI_BASE_PACKAGES $PACKAGES"
 elif [ "$CI_OS_NAME" != "macos" ]; then
   if [[ -n "${APPEND_APT_SOURCES_LIST}" ]]; then
     echo "${APPEND_APT_SOURCES_LIST}" >> /etc/apt/sources.list