diff --git a/src/net_processing.cpp b/src/net_processing.cpp
index b52427d84ba..2e724ad9481 100644
--- a/src/net_processing.cpp
+++ b/src/net_processing.cpp
@@ -2990,8 +2990,19 @@ void ProcessMessage(
         else if (state.GetResult() == TxValidationResult::TX_MISSING_INPUTS)
         {
             bool fRejectedParents = false; // It may be the case that the orphans parents have all been rejected
+
+            // Deduplicate parent txids, so that we don't have to loop over
+            // the same parent txid more than once down below.
+            std::vector<uint256> unique_parents;
+            unique_parents.reserve(tx.vin.size());
             for (const CTxIn& txin : tx.vin) {
-                if (recentRejects->contains(txin.prevout.hash)) {
+                // We start with all parents, and then remove duplicates below.
+                unique_parents.push_back(txin.prevout.hash);
+            }
+            std::sort(unique_parents.begin(), unique_parents.end());
+            unique_parents.erase(std::unique(unique_parents.begin(), unique_parents.end()), unique_parents.end());
+            for (const uint256& parent_txid : unique_parents) {
+                if (recentRejects->contains(parent_txid)) {
                     fRejectedParents = true;
                     break;
                 }
@@ -3000,14 +3011,14 @@ void ProcessMessage(
                 uint32_t nFetchFlags = GetFetchFlags(pfrom);
                 const auto current_time = GetTime<std::chrono::microseconds>();
 
-                for (const CTxIn& txin : tx.vin) {
+                for (const uint256& parent_txid : unique_parents) {
                     // Here, we only have the txid (and not wtxid) of the
                     // inputs, so we only request in txid mode, even for
                     // wtxidrelay peers.
                     // Eventually we should replace this with an improved
                     // protocol for getting all unconfirmed parents.
-                    CInv _inv(MSG_TX | nFetchFlags, txin.prevout.hash);
-                    pfrom.AddKnownTx(txin.prevout.hash);
+                    CInv _inv(MSG_TX | nFetchFlags, parent_txid);
+                    pfrom.AddKnownTx(parent_txid);
                     if (!AlreadyHave(_inv, mempool)) RequestTx(State(pfrom.GetId()), ToGenTxid(_inv), current_time);
                 }
                 AddOrphanTx(ptx, pfrom.GetId());