diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
index 760b1a255fe..f805ba6ddd5 100644
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -440,6 +440,7 @@ inspecting signatures in Mach-O binaries.")
                   "--enable-cet=yes",
                   "--disable-gcov",
                   "--disable-libgomp",
+                  "--disable-libquadmath",
                   "--disable-libsanitizer",
                   building-on)))
         ((#:phases phases)