diff --git a/src/rpc/rawtransaction.cpp b/src/rpc/rawtransaction.cpp
index 396768edb71..f00ee62d7ec 100644
--- a/src/rpc/rawtransaction.cpp
+++ b/src/rpc/rawtransaction.cpp
@@ -604,6 +604,12 @@ static RPCMethod combinerawtransaction()
 {
 
     UniValue txs = request.params[0].get_array();
+
+    // Can't merge < 2 items
+    if (txs.size() < 2) {
+        throw JSONRPCError(RPC_DESERIALIZATION_ERROR, "Missing transactions. At least two transactions required.");
+    }
+
     std::vector<CMutableTransaction> txVariants(txs.size());
 
     for (unsigned int idx = 0; idx < txs.size(); idx++) {
@@ -612,8 +618,21 @@ static RPCMethod combinerawtransaction()
         }
     }
 
-    if (txVariants.empty()) {
-        throw JSONRPCError(RPC_DESERIALIZATION_ERROR, "Missing transactions");
+    { // Test Tx relation for mergeability. Strip scriptSigs and scriptWitnesses to facilitate txId comparison
+        std::vector<CMutableTransaction> tx_variants_copy(txVariants);
+        Txid first_txid{};
+        for (unsigned int k{0}; k < tx_variants_copy.size(); ++k) {
+            // Remove all scriptSigs and scriptWitnesses from inputs
+            for (CTxIn& input : tx_variants_copy[k].vin) {
+                input.scriptSig.clear();
+                input.scriptWitness.SetNull();
+            }
+            if (k == 0) {
+                first_txid = tx_variants_copy[k].GetHash();
+            } else if (first_txid != tx_variants_copy[k].GetHash()) {
+                throw JSONRPCError(RPC_INVALID_PARAMETER, strprintf("Transaction number %d not compatible with first transaction", k+1));
+            }
+        }
     }
 
     // mergedTx will end up with all the signatures; it
diff --git a/test/functional/rpc_createmultisig.py b/test/functional/rpc_createmultisig.py
index 199e9c44fe9..5ed0b255ecf 100755
--- a/test/functional/rpc_createmultisig.py
+++ b/test/functional/rpc_createmultisig.py
@@ -50,6 +50,7 @@ class RpcCreateMultiSigTest(BitcoinTestFramework):
             for output_type in ["bech32", "p2sh-segwit", "legacy"]:
                 self.do_multisig(keys, sigs, output_type)
 
+        self.test_combinerawtransaction_preconditions()
         self.test_multisig_script_limit()
         self.test_mixing_uncompressed_and_compressed_keys(node0)
         self.test_sortedmulti_descriptors_bip67()
@@ -82,7 +83,12 @@ class RpcCreateMultiSigTest(BitcoinTestFramework):
         assert_raises_rpc_error(-8, "Number of keys involved in the multisignature address creation > 20", node1.createmultisig, 16, self.pub, 'p2sh-segwit')
         assert_raises_rpc_error(-8, "Number of keys involved in the multisignature address creation > 20", node1.createmultisig, 16, self.pub, 'bech32')
 
-    def do_multisig(self, nkeys, nsigs, output_type):
+    def test_combinerawtransaction_preconditions(self):
+        self.log.info('Test combinerawtransaction preconditions')
+        # Note that preconditions don't depend on the output type, choosing bech32
+        self.do_multisig(nkeys=3, nsigs=2, output_type="bech32", assert_mergeability=True)
+
+    def do_multisig(self, nkeys, nsigs, output_type, assert_mergeability=False):
         node0, _node1, node2 = self.nodes
         pub_keys = self.pub[0: nkeys]
         priv_keys = self.priv[0: nkeys]
@@ -146,10 +152,32 @@ class RpcCreateMultiSigTest(BitcoinTestFramework):
         assert_equal(rawtx2["complete"], False)
         rawtx3 = node2.signrawtransactionwithkey(rawtx, [priv_keys[-1]], prevtxs)
         assert_equal(rawtx3["complete"], False)
-        assert_raises_rpc_error(-22, "TX decode failed", node2.combinerawtransaction, [rawtx2['hex'], rawtx3['hex'] + "00"])
-        assert_raises_rpc_error(-22, "Missing transactions", node2.combinerawtransaction, [])
-        combined_rawtx = node2.combinerawtransaction([rawtx2["hex"], rawtx3["hex"]])
 
+        if assert_mergeability:
+            # Test boundary conditions
+            assert_raises_rpc_error(-22, "TX decode failed", node2.combinerawtransaction, [rawtx2['hex'], rawtx3['hex'] + "00"])
+            assert_raises_rpc_error(-22, "Missing transactions. At least two transactions required.", node2.combinerawtransaction, [])
+            assert_raises_rpc_error(-22, "Missing transactions. At least two transactions required.", node2.combinerawtransaction, [rawtx2['hex']])
+
+            out_addr2 = getnewdestination('bech32')[2]
+            unmergeable_transaction_args = [
+                ([[{"txid": tx["txid"], "vout": tx["sent_vout"]}], [{out_addr: outval * 2}]], {}), # similar transaction but with different amount to send
+                ([[{"txid": tx["txid"], "vout": tx["sent_vout"]}], [{out_addr: outval}]], {"version": 1}), # similar transaction but with different version
+                ([[{"txid": tx["txid"], "vout": tx["sent_vout"]}], [{out_addr: outval}]], {"locktime": 1}), # similar transaction but with different locktime
+                ([[{"txid": tx["txid"], "vout": tx["sent_vout"]}], [{out_addr2: outval}]], {}), # similar transaction but with different output address (scriptPubKey)
+                ([[{"txid": tx["txid"], "vout": tx["sent_vout"], "sequence": 1}], [{out_addr: outval}]], {}), # similar transaction but with different sequence number
+                ([[{"txid": tx["txid"], "vout": tx["sent_vout"] + 1}], [{out_addr: outval}]], {}) # similar transaction but with different input vout index
+            ]
+
+            for rpc_args, rpc_kwargs in unmergeable_transaction_args:
+                unrelated_tx = node2.createrawtransaction(*rpc_args, **rpc_kwargs)
+                assert_raises_rpc_error(-8, "Transaction number 2 not compatible with first transaction", node0.combinerawtransaction, [rawtx2['hex'], unrelated_tx])
+
+            # Accept duplicate transactions in combinerawtransaction
+            dupe_merged_tx = node2.combinerawtransaction([rawtx2['hex'], rawtx2['hex']])
+            assert_equal(rawtx2['hex'], dupe_merged_tx)
+
+        combined_rawtx = node2.combinerawtransaction([rawtx2["hex"], rawtx3["hex"]])
         tx = node0.sendrawtransaction(combined_rawtx, 0)
         blk = self.generate(node0, 1)[0]
         assert tx in node0.getblock(blk)["tx"]