diff --git a/cmake/bitcoin-build-config.h.in b/cmake/bitcoin-build-config.h.in
index 4783209ef77..fee037e1ba7 100644
--- a/cmake/bitcoin-build-config.h.in
+++ b/cmake/bitcoin-build-config.h.in
@@ -38,9 +38,6 @@
 /* Define if external signer support is enabled */
 #cmakedefine ENABLE_EXTERNAL_SIGNER 1
 
-/* Define this symbol to build code that uses SSE4.1 intrinsics */
-#cmakedefine ENABLE_SSE41 1
-
 /* Define to 1 to enable tracepoints for Userspace, Statically Defined Tracing
    */
 #cmakedefine ENABLE_TRACING 1
diff --git a/cmake/introspection.cmake b/cmake/introspection.cmake
index 0efcf7c63c7..00b15788739 100644
--- a/cmake/introspection.cmake
+++ b/cmake/introspection.cmake
@@ -170,7 +170,6 @@ if(NOT MSVC)
     " HAVE_SSE41
     CXXFLAGS ${SSE41_CXXFLAGS}
   )
-  set(ENABLE_SSE41 ${HAVE_SSE41})
 
   # Check for AVX2 intrinsics.
   set(AVX2_CXXFLAGS -mavx -mavx2)
diff --git a/test/lint/test_runner/src/main.rs b/test/lint/test_runner/src/main.rs
index 073e2dd44cd..be551d627ca 100644
--- a/test/lint/test_runner/src/main.rs
+++ b/test/lint/test_runner/src/main.rs
@@ -620,7 +620,6 @@ fn lint_includes_build_config() -> LintResult {
                     // these cppflags manually.
                     ":(exclude)src/crypto/sha256_arm_shani.cpp",
                     ":(exclude)src/crypto/sha256_avx2.cpp",
-                    ":(exclude)src/crypto/sha256_sse41.cpp",
                     ":(exclude)src/crypto/sha256_x86_shani.cpp",
                 ]),
         )