diff --git a/test/functional/test_framework/util.py b/test/functional/test_framework/util.py
index ceca0d3b19b..08e42a459fa 100644
--- a/test/functional/test_framework/util.py
+++ b/test/functional/test_framework/util.py
@@ -69,6 +69,14 @@ def summarise_dict_differences(thing1, thing2):
             d2[k] = thing2[k]
     return d1, d2
 
+
+def assert_true(condition: bool) -> None:
+    """Separate from the `assert` keyword in that it should not be optimized out
+    when environment var `PYTHONOPTIMIZE=1`, or Python is run with `-O`."""
+    if not condition:
+        raise AssertionError
+
+
 def assert_equal(thing1, thing2, *args):
     if thing1 != thing2 and not args and isinstance(thing1, dict) and isinstance(thing2, dict):
         d1,d2 = summarise_dict_differences(thing1, thing2)
diff --git a/test/functional/wallet_multisig_descriptor_psbt.py b/test/functional/wallet_multisig_descriptor_psbt.py
index 23a9a4cc755..5f5c79434e0 100755
--- a/test/functional/wallet_multisig_descriptor_psbt.py
+++ b/test/functional/wallet_multisig_descriptor_psbt.py
@@ -11,6 +11,7 @@ from test_framework.test_framework import BitcoinTestFramework
 from test_framework.util import (
     assert_approx,
     assert_equal,
+    assert_true,
 )
 
 
@@ -68,7 +69,7 @@ class WalletMultisigDescriptorPSBTTest(BitcoinTestFramework):
                     "timestamp": "now",
                 },
             ])
-            assert all(r["success"] for r in result)
+            assert_true(all(r["success"] for r in result))
             yield multisig
 
     def run_test(self):
@@ -95,9 +96,9 @@ class WalletMultisigDescriptorPSBTTest(BitcoinTestFramework):
         self.log.info("Check that every participant's multisig generates the same addresses...")
         for _ in range(10):  # we check that the first 10 generated addresses are the same for all participant's multisigs
             receive_addresses = [multisig.getnewaddress() for multisig in participants["multisigs"]]
-            all(address == receive_addresses[0] for address in receive_addresses)
+            assert_true(all(address == receive_addresses[0] for address in receive_addresses))
             change_addresses = [multisig.getrawchangeaddress() for multisig in participants["multisigs"]]
-            all(address == change_addresses[0] for address in change_addresses)
+            assert_true(all(address == change_addresses[0] for address in change_addresses))
 
         self.log.info("Get a mature utxo to send to the multisig...")
         coordinator_wallet = participants["signers"][0]