diff --git a/contrib/guix/manifest.scm b/contrib/guix/manifest.scm
index 40bbaf68b55..732f65da30d 100644
--- a/contrib/guix/manifest.scm
+++ b/contrib/guix/manifest.scm
@@ -131,7 +131,10 @@ desirable for building Bitcoin Core release binaries."
 (define (make-mingw-pthreads-cross-toolchain target)
   "Create a cross-compilation toolchain package for TARGET"
   (let* ((xbinutils (binutils-mingw-patches (cross-binutils target)))
-         (pthreads-xlibc mingw-w64-x86_64-winpthreads)
+         (machine (substring target 0 (string-index target #\-)))
+         (pthreads-xlibc (make-mingw-w64 machine
+                                         #:xgcc (cross-gcc target #:xgcc (gcc-mingw-patches base-gcc))
+                                         #:with-winpthreads? #t))
          (pthreads-xgcc (cross-gcc target
                                     #:xgcc (gcc-mingw-patches mingw-w64-base-gcc)
                                     #:xbinutils xbinutils