diff --git a/src/serialize.h b/src/serialize.h
index 19585c630ab..a0b012b25c8 100644
--- a/src/serialize.h
+++ b/src/serialize.h
@@ -710,14 +710,12 @@ template<typename Stream, typename C> void Unserialize(Stream& is, std::basic_st
 
 /**
  * prevector
- * prevectors of unsigned char are a special case and are intended to be serialized as a single opaque blob.
  */
 template<typename Stream, unsigned int N, typename T> inline void Serialize(Stream& os, const prevector<N, T>& v);
 template<typename Stream, unsigned int N, typename T> inline void Unserialize(Stream& is, prevector<N, T>& v);
 
 /**
  * vector
- * vectors of unsigned char are a special case and are intended to be serialized as a single opaque blob.
  */
 template<typename Stream, typename T, typename A> inline void Serialize(Stream& os, const std::vector<T, A>& v);
 template<typename Stream, typename T, typename A> inline void Unserialize(Stream& is, std::vector<T, A>& v);
@@ -820,10 +818,9 @@ void Unserialize(Stream& is, std::basic_string<C>& str)
 template <typename Stream, unsigned int N, typename T>
 void Serialize(Stream& os, const prevector<N, T>& v)
 {
-    if constexpr (std::is_same_v<T, unsigned char>) {
+    if constexpr (BasicByte<T>) { // Use optimized version for unformatted basic bytes
         WriteCompactSize(os, v.size());
-        if (!v.empty())
-            os.write(MakeByteSpan(v));
+        if (!v.empty()) os.write(MakeByteSpan(v));
     } else {
         Serialize(os, Using<VectorFormatter<DefaultFormatter>>(v));
     }
@@ -833,7 +830,7 @@ void Serialize(Stream& os, const prevector<N, T>& v)
 template <typename Stream, unsigned int N, typename T>
 void Unserialize(Stream& is, prevector<N, T>& v)
 {
-    if constexpr (std::is_same_v<T, unsigned char>) {
+    if constexpr (BasicByte<T>) { // Use optimized version for unformatted basic bytes
         // Limit size per read so bogus size value won't cause out of memory
         v.clear();
         unsigned int nSize = ReadCompactSize(is);
@@ -856,10 +853,9 @@ void Unserialize(Stream& is, prevector<N, T>& v)
 template <typename Stream, typename T, typename A>
 void Serialize(Stream& os, const std::vector<T, A>& v)
 {
-    if constexpr (std::is_same_v<T, unsigned char>) {
+    if constexpr (BasicByte<T>) { // Use optimized version for unformatted basic bytes
         WriteCompactSize(os, v.size());
-        if (!v.empty())
-            os.write(MakeByteSpan(v));
+        if (!v.empty()) os.write(MakeByteSpan(v));
     } else if constexpr (std::is_same_v<T, bool>) {
         // A special case for std::vector<bool>, as dereferencing
         // std::vector<bool>::const_iterator does not result in a const bool&
@@ -877,7 +873,7 @@ void Serialize(Stream& os, const std::vector<T, A>& v)
 template <typename Stream, typename T, typename A>
 void Unserialize(Stream& is, std::vector<T, A>& v)
 {
-    if constexpr (std::is_same_v<T, unsigned char>) {
+    if constexpr (BasicByte<T>) { // Use optimized version for unformatted basic bytes
         // Limit size per read so bogus size value won't cause out of memory
         v.clear();
         unsigned int nSize = ReadCompactSize(is);
diff --git a/src/span.h b/src/span.h
index 2c27a54fc76..c974c265cec 100644
--- a/src/span.h
+++ b/src/span.h
@@ -287,9 +287,11 @@ Span<std::byte> MakeWritableByteSpan(V&& v) noexcept
 // Helper functions to safely cast basic byte pointers to unsigned char pointers.
 inline unsigned char* UCharCast(char* c) { return reinterpret_cast<unsigned char*>(c); }
 inline unsigned char* UCharCast(unsigned char* c) { return c; }
+inline unsigned char* UCharCast(signed char* c) { return reinterpret_cast<unsigned char*>(c); }
 inline unsigned char* UCharCast(std::byte* c) { return reinterpret_cast<unsigned char*>(c); }
 inline const unsigned char* UCharCast(const char* c) { return reinterpret_cast<const unsigned char*>(c); }
 inline const unsigned char* UCharCast(const unsigned char* c) { return c; }
+inline const unsigned char* UCharCast(const signed char* c) { return reinterpret_cast<const unsigned char*>(c); }
 inline const unsigned char* UCharCast(const std::byte* c) { return reinterpret_cast<const unsigned char*>(c); }
 // Helper concept for the basic byte types.
 template <typename B>