diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 3801c187faa..a24f0afdb95 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -540,7 +540,7 @@ jobs:
             timeout-minutes: 150
             file-env: './ci/test/00_setup_env_native_fuzz_with_msan.sh'
 
-          - name: 'MSan, depends'
+          - name: 'MSan'
             cirrus-runner: 'ghcr.io/cirruslabs/ubuntu-runner-amd64:24.04-lg'
             fallback-runner: 'ubuntu-24.04'
             timeout-minutes: 120
diff --git a/ci/test/00_setup_env_native_msan.sh b/ci/test/00_setup_env_native_msan.sh
index 4ff82614e9d..c0559fc69cc 100755
--- a/ci/test/00_setup_env_native_msan.sh
+++ b/ci/test/00_setup_env_native_msan.sh
@@ -22,6 +22,8 @@ export CI_LIMIT_STACK_SIZE=1
 # Setting CMAKE_{C,CXX}_FLAGS_DEBUG flags to an empty string ensures that the flags set in MSAN_FLAGS remain unaltered.
 # _FORTIFY_SOURCE is not compatible with MSAN.
 export BITCOIN_CONFIG="\
+ --preset=dev-mode \
+ -DBUILD_GUI=OFF \
  -DCMAKE_BUILD_TYPE=Debug \
  -DCMAKE_C_FLAGS_DEBUG='' \
  -DCMAKE_CXX_FLAGS_DEBUG='' \