diff --git a/src/crypto/sha256_sse4.cpp b/src/crypto/sha256_sse4.cpp
index 2d37d124d1e..4464ec92439 100644
--- a/src/crypto/sha256_sse4.cpp
+++ b/src/crypto/sha256_sse4.cpp
@@ -12,18 +12,23 @@
 
 namespace sha256_sse4
 {
-void Transform(uint32_t* s, const unsigned char* chunk, size_t blocks)
-#if defined(__clang__)
-  /*
-  clang is unable to compile this with -O0 and -fsanitize=address.
-  See upstream bug: https://github.com/llvm/llvm-project/issues/92182.
-  This also fails to compile with -O2, -fcf-protection & -fsanitize=address.
-  See https://github.com/bitcoin/bitcoin/issues/31913.
-  */
-#if __has_feature(address_sanitizer)
+/*
+Both Clang and GCC fail with ASan on this inline assembly:
+- Clang: compile failure with -O0 or -O2 + -fcf-protection under ASan.
+  See https://github.com/llvm/llvm-project/issues/92182
+  and https://github.com/bitcoin/bitcoin/issues/31913.
+- GCC: runtime SEGV during SHA256AutoDetect()'s self-test under ASan,
+  regardless of optimization level.
+  See https://github.com/bitcoin/bitcoin/issues/34881.
+*/
+#if defined(__SANITIZE_ADDRESS__)
+  __attribute__((no_sanitize("address")))
+#elif defined(__clang__)
+#if __has_feature(address_sanitizer) // fallback can be removed once support for Clang 21 is dropped
   __attribute__((no_sanitize("address")))
 #endif
 #endif
+void Transform(uint32_t* s, const unsigned char* chunk, size_t blocks)
 {
     static const uint32_t K256 alignas(16) [] = {
         0x428a2f98, 0x71374491, 0xb5c0fbcf, 0xe9b5dba5,